R848;S28463 瑞喹莫德 Resiquimod
- 公司名稱 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型號 R848;S28463
- 產地
- 廠商性質 生產廠家
- 更新時間 2019/7/11 17:11:55
- 訪問次數 650
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供貨周期 | 現貨 | 規格 | 10 mM * 1 mL;10 mg;25 mg |
---|---|---|---|
貨號 | HY-13740 | 應用領域 | 生物產業 |
Resiquimod
產品活性:Resiquimod是一種Toll樣受體7和8 (TLR7/TLR8) 的激動劑, 誘導細胞因子如TNF-α,IL-6和IFN-α的上調。
研究領域:Immunology/Inflammation
作用靶點:Toll-like Receptor (TLR)
In Vitro: Resiquimod (R-848) induces both hapten- and allergen-specific circulating T cells, including TH2 effectors, to produce IFN-γ and even to lose the ability to produce IL-4. Resiquimod (R848) enhances PBL proliferation in a dose-dependent manner, and increases the number of BrdU-positive cells in BrdU incorporation assay. Cells treated with R848 exhibits significantly increased (3.5-fold) luciferase (a reporter of NF-κB activity) activity.
In Vivo: Resiquimod (R-848) (50 μg/bird, i.m. route) significantly up-regulates the expression of IFN-α, IFN-β, IFN-γ, IL-1β, IL-4, iNOS and MHC-II genes in SPF chicken.
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