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技術文章

測量應用案例-20210409

閱讀:126          發布時間:2021-5-20
 

文獻名:Nanoemulsion for improving the oral bioavailability of hesperetin: formulation optimization and absorption mechanism

 

 

作者Fanyu Zenga; Dandan Wanga; Yan Tiana; Min Wanga; Rui Liua; Zhining Xiaa; Yike Huangb

a School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

b College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

 

 

摘要:This study aimed to prepare a nanoemulsion vehicle to improve the oral bioavailability of hesperetin. The pseudo-ternary phase diagrams and the RSM were used to optimize nanoemulsion parameters. Compared with hesperetin suspension, the AUC0-t and Cmax of nanoemulsion were increased by 5.67-fold and 2.64-fold, respectively. The proportion of lymphatic transport reached 87.72%, the cumulative absorption amount of jejunum, ileum, and duodenum increased by 1.1-fold, 1.92-fold, and 1.5-fold, respectively. The results implied that hesperetin nanoemulsion could effectively improve the bioavailability of hesperetin by increasing lymphatic transport and enhancing intestinal permeability. Therefore, nanoemulsion is a potential method to improve the bioavailability of hesperetin, which has strong practicability.

 

 

關鍵詞:Nanodrug; Intestinal absorption; Hesperetin; Bioavailability; Pharmacokinetics

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