13SHD001(Dap22)-ShK (Stichodactyla toxin)
【簡單介紹】
【詳細說明】
(Dap22)-ShK (Stichodactyla toxin)
Selective blocker of Kv1.3(鉀離子通道Kv1.3選擇性阻斷劑)
(Dap22)-ShK (ShK Dap22) peptide is a synthetic derivative of the well-known ShK toxin #08SHK001 (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6 (KCNA6) respectively with a Kd of 11 pM,16 pM, 312 pM and 165 pM. In (Dap22)-ShK, lysine22 has been replaced by a diaminopropionic acid (Dap) residue that greatly improves the selectivity of the peptide for the voltage-gated potassium channel Kv1.3 (IC50 around 23 pM) against Kv1.1 (1.8 nM), Kv1.4 (37 nM) and Kv1.6 (10 nM) channels. The high selectivity of (Dap22)-Shk is achieved thanks to the strong binding between the Dap and His404 / Asp386 residues of Kv1.3 channel. (Dap22)-ShK inhibits T cell proliferation induced by anti-CD3 at subnanomolar concentrations.
(Dap22)-ShK 技術資料
氨基酸序列:
Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Dap-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OH
二硫鍵: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32
長度 (aa):35
分子式:C166H268N54O48S7
分子量:4012.8 Da
外觀:White lyophilized solid
可溶性: water and saline buffer
CAS 號:220384-25-8
來源: Synthetic
純度: > 97%
產品信息
13SHD001-00010 | (Dap22)-ShK | 0.01mg |
13SHD001-50010 | (Dap22)-ShK | 5 x 0.01mg |
13SHD001-00100 | (Dap22)-ShK | 0.5mg |
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