08CON009Conantokin-G(芋螺抑制肽-G)
【簡單介紹】
【詳細說明】
Conantokin-G(芋螺抑制肽G)
Selective inhibitor of NR2B-containing NMDAR
NMDAR(N-甲基-D-天冬氨酸受體)亞單位NR2B的選擇性抑制劑
Conantokin-G has been isolated from the venom of the cone Conus geographus. Conantokin-Gselectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Thus, Conantokin-G inhibits in a concentration-dependent manner the Ca2+ influx leading to a neuroprotective effect against NMDA-induced excitotoxicity. Conantokin-G was shown to block NMDA-evoked currents in murine cortical neurons with an IC50 value of around 480 nM.
Conantokin-G 技術資料
氨基酸序列: Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2
長度 (aa):17
分子式: C88H138N26O44
分子量: 2264.23 Da
外觀: White lyophilized solid
可溶性:water and saline buffer
CAS 號: [93438-65-4]
來源: Synthetic
純度:> 94.5 %
產品信息
08CON009-00500 | Conantokin-G | 0.5mg |
08CON009-01000 | Conantokin-G | 1mg |
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