TACSTD2抗體

抗原
Tumor-Associated Calcium Signal Transducer 2 (TACSTD2)
別名 Tpm-2, Trop-2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, C80403, Ly97, Prp1
抗原表位
其他選擇 AA 1-274
AA 1-274(17),C-Term (10),Internal Region (10),AA 218-246 (7),AA 27-274 (4),AA 1-270 (2),AA 162-190 (2),Extracellular Domain (2),AA 1-47 (1),AA 19-294 (1),AA 275-303 (1),AA 82-268 (1),Center (1),Middle Region (1),N-Term (1),Phe167 (1)
適用
其他選擇 Human
Human(77),Murine (48),Rat ((Rattus)) (34),Bovine (13),Dog (Canine) (13),Chicken (12),Pig (Porcine) (1)
宿主
其他選擇 Mouse
Rabbit(72),Mouse (10),Goat (8),Rat (1)
克隆類型 (克隆位點)
單克隆 (8C6C1D7)
標(biāo)記
其他選擇 非結(jié)合性
FITC(7),PE (4),APC (3),Biotin (3),HRP (3),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),CF (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),Alkaline Phosphatase (AP) (1)
應(yīng)用范圍
其他選擇 Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)
Western Blotting (WB)(47),ELISA (38),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (19),Immunohistochemistry (IHC) (14),Flow Cytometry (FACS) (12),Immunofluorescence (IF) (8),Immunocytochemistry (ICC) (7),Enzyme Immunoassay (EIA) (2),Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
規(guī)格 50 μg
發(fā)貨至 中國 (更改)

TACSTD2抗體

產(chǎn)品細節(jié)

圖像 貯存及處理 使用細節(jié) 目標(biāo)詳細情況 回頁首

產(chǎn)品細節(jié)

顯示 隱藏
免疫原 Recombinant human TROP2 protein
克隆位點 8C6C1D7
亞型 IgG1
特異性 Human TROP2 / TACSTD2
交叉反應(yīng) （詳細） No cross-reactivity in WB and ELISA with Human BCAM / CD239 Human VCAM1 / CD106 Human ICAM1 / CD54 Human CD146 / MCAM / MUC18 Human CD171 / NCAML1 / L1CAM Human Cadherin-1 / E-cadherin / CDH1 / CD324 Cross reactivity Does not react with Mouse, RatDoes not react with Mouse, Rat
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human TROP2 extracellular domain (rh TROP2, NP_002344.2, Met 1-Thr 274). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細情況

圖像 貯存及處理 使用細節(jié) 回頁首

目標(biāo)詳細情況

顯示 隱藏
別名 TACSTD2
背景 Human TROP2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed by human carcinomas. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. The cytoplasmic tail of TROP2 possesses potential serine and tyrosine phosphorylation sites and a conserved phosphatidyl-inositol binding consensus sequence. TROP2 transduces an intracellular calcium signal and acts as a cell surface receptor, meanwhile is involved in the regulation of cell- cell adhesion. Accordingly, as a widespread stimulator of human cancer growth and a unique marker and causal factor of metastatic cancer, TROP2 is a possible candidate for diagnosis and molecular target therapy. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
NCBI Accession NP_002344.2

使用細節(jié)

圖像 貯存及處理 目標(biāo)詳細情況 回頁首

使用細節(jié)

顯示 隱藏
應(yīng)用備注 Immunochemistry - IHC-P: 5-15 μg/mL ICC/IF: 15-30 μg/mL
限制 For Research Use only

貯存及處理

圖像 使用細節(jié) 目標(biāo)詳細情況 回頁首

貯存及處理

顯示 隱藏
緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

xy-0539R Chromogranin A嗜鉻粒素A抗體
xy-0791R CGRPCGRP降鈣素基因相關(guān)肽抗體
xy-0042R ChATChAT膽堿乙酰轉(zhuǎn)移酶抗體
xy-9740R CNTD2細胞周期蛋白N端結(jié)構(gòu)域蛋白2抗體
xy-8550R Coronin 1a肌動蛋白結(jié)合蛋白CORO1A抗體
xy-2080R Cecropin抗菌肽/天蠶素抗體
xy-1809R Camk1g鈣/鈣調(diào)蛋白依賴蛋白激酶IG抗體
xy-1679R CCR8細胞表面趨化因子受體8抗體
xy-0262R CMTM2趨化素樣因子超家族成員2抗體
xy-9515R CTH胱硫醚γ裂解酶抗體
xy-1277R CFTR囊性纖維化跨膜轉(zhuǎn)運調(diào)節(jié)因子抗體
xy-1330R CKIP-1酪蛋白激酶2相互作用蛋白1抗體
xy-1286R CD40LCD40L抗體
xy-10033R Alpha s1 Caseinα-s1酪蛋白抗體
xy-0716R CIDEBCIDEB抗體
xy-1186R Scavenging Receptor SR-BI高密度脂蛋白受體/清道夫受體抗體
xy-9124R COPS7A信號轉(zhuǎn)導(dǎo)蛋白亞基7A抗體
xy-0615R Survivin細胞凋亡抑制因子抗體
xy-0936R Clostridium perfringens type DD型產(chǎn)氣莢膜梭菌抗體
xy-0063R Calcitonin降鈣素抗體
xy-15094R C20orf1420號染色體開放閱讀框14抗體
xy-0743R CTGF結(jié)締組織生長因子抗體
xy-1179R CTLA4細胞毒性T細胞抗原-4抗體
xy-0124R Calcitonin receptor降鈣素受體抗體
xy-15065R C1orf381號染色體開放閱讀框38抗體
xy-0727R CXorf36脫羧酶蛋白體36抗體
xy-1050R Connexin-40間隙連接蛋白40抗體
xy-0651R Connexin 43間隙連接蛋白43抗體
xy-0652R Connexin-45間隙連接蛋白45抗體