轉錄因子蛋白SIM1抗體

英文名稱 SIM1
中文名稱 轉錄因子蛋白SIM1抗體
別    名 bHLHe14; Class E basic helix-loop-helix protein 14; SIM1; SIM1_HUMAN; Single minded homolog 1; Single-minded homolog 1.

說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  神經生物學  信號轉導  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIM1 (2-80aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors. Several PAS domain family members have been identified including AhR, Arnt 1, and single-minded proteins (SIM1 and SIM2). The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand-dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element. Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, thus inhibiting transcriptional activation. The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, which is located on chromosome 21, is a candidate for the gene responsible for Down syndrome.

Function:
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT.

Subcellular Location:
Nucleus.xy-6836R    GAS2L1生長停滯特異性蛋白2家族1抗體
xy-9701R    GPR97 G蛋白偶聯受體97抗體
xy-13305R    GBP7G蛋白結合蛋白7抗體
xy-0890R    GFP綠色熒光蛋白抗體
xy-0844R    GFP綠色熒光蛋白抗體
xy-9126R    GPS1G蛋白通路抑制蛋白1抗體
xy-0054R    GDNF Receptor alpha 2膠質細胞系源性神經營養因子受體α2抗體
xy-0622R    gamma Synuclein核突觸蛋白-γ抗體
xy-0999R    GM-CSF粒細胞-巨噬細胞克隆刺激因子抗體
xy-0837R    GLUR/glutathione reductase谷胱甘肽還原酶抗體
xy-0933R    GLP-1胰高血糖素樣肽-1抗體
xy-0823R    Granulin顆粒蛋白前體抗體
xy-2426R    Glypican 1磷脂酰基醇蛋白聚糖1抗體
xy-2091R    GSK3 alpha糖原合酶激酶3α抗體
xym-0972M    Gentamicin(3G7)慶大霉素單克隆抗體
xy-5160R    GSTO1谷胱甘肽硫轉移酶ω1抗體
xy-2383R    GJB3間隙連接蛋白31抗體
xy-2396R    GNMT甘氨酸-N-甲基轉移酶
xy-1469R    GRP75G蛋白偶聯受體75抗體
xy-1778R    GATA4GATA結合蛋白4抗體
xy-2252R    GABA兔抗γ1氨基丁酸抗體
xy-15364R    GPR85G蛋白偶聯受體GPR85蛋白抗體
xy-0972R    Gentamicin慶大霉素抗體
xy-1699R    Galectin 9半乳糖凝集素9抗體
xy-2139R    GRM2+GRM4促代謝型谷氨酸受體2+4抗體
xy-2684R    GPNMBGPNMB抗體
xy-10457R    GGT2 light chainγ谷氨酰轉肽酶2輕鏈抗體
xy-10458R    GGT5 light chainγ-谷氨酰轉肽酶5輕鏈抗體
xy-10459R    GGT7 light chainγ-谷氨酰轉肽酶7輕鏈抗體
xy-10460R    GNPTAB溶酶體累積病相關蛋白/口吃相關蛋白抗體
xy-7332R    GSK3 Alpha + Beta糖原合酶激酶3α+β抗體
xy-2516R    GTSE-1G2期/S期應答相關蛋白1抗體
xy-2227G    GDF8生長分化因子8/肌肉抑制素抗體
xy-2073R    phospho-GSK3 Alpha + Beta (Tyr279+Tyr216)磷酸化糖原合酶激酶3α/β抗體