磷酸肌醇磷酸酶蛋白INPP5G抗體

英文名稱 Synaptojanin
中文名稱 磷酸肌醇磷酸酶蛋白INPP5G抗體
別    名 5-trisphosphate 5-phosphatase 1; Inositol 5' phosphatase; INPP 5G; INPP5G; KIAA0910; Polyphosphoinositide phosphatase; Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1; Synaptic inositol 145 trisphosphate 5 phosphatase 1; Synaptic inositol-1 antibody Synaptic inositol-145-trisphosphate 5-phosphatase 1; Synaptojanin 1; Synaptojanin 1 polyphosphoinositide phosphatase; Synaptojanin-1; Synaptojanin1; Synj 1; Synj1; SYNJ1_HUMAN.
   
說 明 書 0.2ml  
研究領域 細胞生物  神經生物學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 173kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Synaptojanin/INPP5G
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Synaptojanins are characterized by an N-terminal SAC1-like sequence, a central 5-phosphate domain, and a unique C-terminal sequence and have been shown to use phosphatidylinositol 4,5-bisphosphate as a substrate. Synaptojanins exist as two isoforms, synaptojanin 1 and 2, which differ in the C-terminal domain, and each isoform has multiple variants produced by alternative splicing. Synaptojanin 1 is expressed as two major forms: the shorter is found in brain while the longer is expressed in peripheral tissues. Eight splice variants of synaptojanin 2 have been detected, including a brain specific isoform. Synaptojanins are thought to participate in the endocytosis of synaptic vesicles and the regulation of the actin cytoskeleton.

Function:
Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.

Subunit:
Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Binds AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain).

Subcellular Location:
Cytoplasm.xy-5402R    KCNC1離子通道蛋白Kv3.1抗體
xy-3799R    KLK11激肽釋放酶11抗體
xy-3800R    Kappa Light Chaink輕鏈抗體
xy-6260R    KIST絲氨酸/蘇氨酸蛋白激酶KIST抗體（激酶相互作用與白血病相關基因）
xy-11027R    KIF5A/NKHC1驅動蛋白KIF5A抗體
xy-8517R    KCC2神經細胞鉀氯離子轉運蛋白抗體
xy-1033R    KRAS原癌基因K-ras抗體
xy-0749R    Kisspeptin腫瘤轉移抑制基因抗體
xy-0225R    KLH血藍蛋白抗體
xy-9857R    KCNG2心臟鉀離子通道蛋白亞基2抗體
xy-8358R    KLHDC8AKLHDC8A蛋白抗體
xy-4894R    Keratan Sulfate硫酸角質素抗體
xy-1577R    KLF13腸道內富含的Kruppel樣因子13
xy-9382R    ZFP103鋅指蛋白103抗體
xy-0734R    KGF纖維母細胞生長因子7抗體
xy-2772R    KLF2肺Kruppel樣因子抗體
xy-5869R    KLK5激肽釋放酶5抗體
xy-5866R    KLK13激肽釋放酶13抗體
xy-5867R    KLK15激肽釋放酶15抗體
xy-5868R    KLK2激肽釋放酶2抗體
xy-5865R    KLK12激肽釋放酶12抗體
xy-2501R    KiSS1 receptorG蛋白偶聯(lián)受體54抗體
xy-3527R    KIF17驅動蛋白家族KIF17抗體
xy-3644R    KLF9轉錄因子KLF9抗體
xy-2531R    NES/KLK10上皮細胞特異性蛋白1抗體
xy-5403R    phospho-KCNC1(Ser503)磷酸化離子通道蛋白Kv3.1抗體
xy-2812R    KAT4細胞周期基因1蛋白抗體
xy-2385R    KLF5驅動蛋白KIF5B抗體
xy-7752R    KLHL13kelch樣蛋白13抗體
xy-11569R    KCNN3鈣激活鉀通道蛋白3抗體
xy-11570R    KIBRA腎臟和腦蛋白抗體
xy-7751R    KIF2B有絲分裂驅動蛋白樣2B抗體