突觸相關蛋白102抗體

英文名稱 MPP3/SAP102
中文名稱 突觸相關蛋白102抗體
別    名 Discs large Drosophila homolog 3; Discs large homolog 3 neuroendocrine dlg Drosophila; Discs large homolog 3; Discs large homolog 3 Drosophila; Discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG 3; DLG3; DLG3_HUMAN; MPP3; MPP-3; KIAA1232; mKIAA1232; MRX 90; MRX; MRX90; NE Dlg; NEDLG; Neuroendocrine dlg; Neuroendocrine-DLG; OTTHUMP00000023475; OTTHUMP00000023476; OTTHUMP00000023477; SAP 102; SAP-102; SAP102; Synapse associated protein 102; Synapse-associated protein 102; XLMR; bA291O7.3; bA291O7.3 discs large Drosophila homolog 3 neuroendocrine dlg.
  
說 明 書 0.2ml  
研究領域 細胞生物  神經生物學  信號轉導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAP102
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 產 商 BIOSS
PubMed PubMed
產品介紹 background:
MPP3, also known as Discs large homolog 3 (DLG3), is a 585 amino acid protein belonging to the MAGUK family. Proteins in the MAGUK family, including CASK, ZO-1, ZO-2, p55 and MPP2, are known to regulate cell proliferation, intracellular junctions and signaling pathways by interacting with the cytoskeleton. MPP3 contains one guanylate kinase-like domain, one PDZ domain, two L27 domains and one SH3 domain. Via the PDZ domain, MMP3 interacts with the C-terminus of TSLC1. MMP3 has also been found to interact with SR-2A and SR-4.

Function:
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

Subunit:
Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4.

DISEASE:
Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300189]. Mental retardation is characterized by significantly sub-average general inlectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

Similarity:
Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 4356 Human

Omim: 601114 Human

SwissProt: Q13368 Human

Unigene: 396566 Humanxy-5383R    Phospho-NMDAR2B (Ser1303)磷酸化谷氨酸受體2B抗體
xy-3957R    NDUFA10NADH氧化還原酶輔酶10抗體
xy-6204R    NCKAP1膜相關的蛋白質HEM2抗體
xy-2378R    Notch 2跨膜受體蛋白Notch-2抗體
xy-3191R    Phospho-IKB beta (Ser23) 磷酸化KB抑制蛋白β抗體
xy-5509R    Phospho-NFKB1 (Ser903)磷酸化細胞核因子p50/k基因結合核因子抗體
xy-3812R    NEDD8泛素樣蛋白NEDD8抗體
xy-8171R    NFIC核因子1C型抗體
xy-5527R    phospho-NPTX1(Tyr344)磷酸化神經細胞正五聚體1抗體
xy-8857R    RNA結合蛋白抗體
xy-8535R    phospho-NFATC4 (Ser168 + Ser170)磷酸化T細胞激活核轉錄因子4抗體
xy-12867R    NR1H4膽汁酸受體抗體
xy-12400R    NKAPNFKB激活蛋白抗體
xy-12401R    NLE1NLE1蛋白抗體
xy-13072R    Phospho-eNOS (Ser116)磷酸化一氧化氮合成酶3（內皮型）抗體
xy-13073R    Phospho-eNOS (Ser615)磷酸化一氧化氮合成酶3（內皮型）抗體
xy-13074R    Phospho-eNOS (Ser632)磷酸化一氧化氮合成酶3（內皮型）抗體
xy-10376R    Orexin A增食欲素A/欲激素A抗體
xy-15509R    Orexin A增食欲素A/欲激素A抗體
xy-7344R    OAS32'-5'-寡腺苷酸合成酶3抗體
xy-12377R    OSR2牙齒發育相關蛋白Osr2抗體
xy-3816R    Oct-4B(OCT4B-190)NT胚胎干細胞關鍵蛋白190抗體(N端)
xy-8998R    ORC1L起始識別復合蛋白亞基1抗體
xy-6236R    OTUB泛素特異性蛋白酶Otubain2抗體
xy-11469R    Oligophrenin 1精神發育遲滯相關蛋白Oligophrenin-1抗體
xy-8404R    OGFOD2末端多聚腺苷酸2蛋白抗體
xy-6559R    ORAV1口腔癌高表達的蛋白1抗體
xy-6560R    ORP4氧化固醇結合蛋白4抗體
xy-6558R    OLFM4抗細胞凋亡蛋白OLFM44抗體
xy-6556R    OCC1結腸癌過度表達蛋白1抗體
xy-6557R    OCIAD2卵巢癌免疫反應抗原抗體
xy-5714R    OVCA1卵巢癌相關基因1抗體
xy-5723R    OSGIN1氧化應激誘導生長抑制因子1抗體
xy-6334R    ORP8氧化固醇結合蛋白8抗體
xy-11229R    OTUB1泛素特異性蛋白酶OTB1抗體