中斷位點蛋白STIL抗體

英文名稱 STIL
中文名稱 中斷位點蛋白STIL抗體
別    名 MCPH7; SCL interrupting locus protein; SCL-interrupting locus protein; SCL/TAL1 interrupting locus; SIL; STIL; STIL_HUMAN; TAL 1 interrupting locus protein; TAL-1-interrupting locus protein.

說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Cow, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 143kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human STIL
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
TAL1 disruption at 1p32, a common rearrangement in the T-cell acute lymphoblastic leukemia, usually results in the formation of a SCL interrupting locus (SIL)-TAL1 fusion product. SIL is an immediate early gene whose expression is associated with cell proliferation. The Sil protein exhibits ubiquitous expression in hematopoietic cell lines and tissues. However, Sil protein levels remain tightly regulated during the cell cycle, achieving peak levels in mitosis and diminishing on transition to G1 phase. Overexpression of Sil in primary adenocarcinomas predicts metastatic spread, especially in lung tumors with increased mitotic activity. 

Function:
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. xy-5620R    phospho-STAT5a(Ser780)磷酸化信號轉導和轉錄激活因子5a抗體
xy-5636R    phospho-SYT6 (Thr418)磷酸化突觸蛋白6抗體
xy-5624R    phospho-Src(Tyr215)磷酸化Src原癌基因抗體
xy-2926R    Syndecan 4多配體聚糖4抗體
xy-5892R    ST14絲氨酸蛋白酶14/膜型絲氨酸蛋白酶1抗體
xy-6252R    SIK1絲氨酸/蘇氨酸蛋白激酶SIK1抗體
xy-2962R    Syncytin 1合胞素1抗體
xy-7016R    SDCCAG16結腸癌抗原16抗體
xy-3426R    phospho-Src(Tyr418)磷酸化Src原癌基因抗體
xy-13666R    STAC2STAC2蛋白抗體
xy-13611R    SOX30轉錄因子SOX30抗體
xy-13602R    SLAIN113號染色體開放閱讀框32抗體
xy-13617R    SMCP精子線粒體相關富含半胱氨酸蛋白抗體
xy-13701R    SIT跨膜接頭蛋白SIT抗體
xy-13702R    SKAP55SKAP55蛋白抗體
xy-7350R    SIRT2沉默調節相關蛋白2抗體
xy-13618R    SPANXB1腫瘤/睪丸抗原11.2抗體
xy-13740R    Smoothelin平滑肌蛋白抗體
xy-13735R    SHROOM1SHROOM1蛋白抗體
xy-3416R    Phospho-SirT1 (Ser27)磷酸化沉默調節蛋白1抗體
xy-12144R    SHC2SCK蛋白抗體
xy-0962R    SLC34A2磷酸鈉協同轉運蛋白抗體
xy-4862R    SORBS2精氨酸結合蛋白2抗體
xy-0794R    Sialoadhesin唾液酸結合性免疫球蛋白樣凝集素1抗體
xy-12135R    Striatin 3細胞周期蛋白SG2N抗體
xy-12136R    Striatin 4STRN4蛋白抗體
xy-12127R    SCN7A鈉離子通道蛋白7α/Na+ CP type VIIα抗體
xy-12133R    SCN3A電壓門控鈉通道SCN3α蛋白/Na+ CP type IIIα抗體
xy-12122R    SCN2B神經元電壓門控鈉通道蛋白β2/Na+ CP type IIβ抗體
xy-12123R    STOM紅細胞膜蛋白STOM抗體
xy-12124R    SLC6A7/PROT鈉依賴性脯氨酸轉運PROT抗體
xy-12125R    SLC38A2/SNAT2氨基酸轉運蛋白2抗體
xy-12118R    SLC35C2溶質載體蛋白家族35成員C2抗體
xy-12119R    SRCAP轉綠激活蛋白SRCAP抗體