信號傳導T淋巴細胞活化相關蛋白抗體

英文名稱 SH2D1A
中文名稱 信號傳導T淋巴細胞活化相關蛋白抗體
別    名 SH2 domain protein 1A; DSHP; Duncan disease SH2 protein; SAP; Signaling lymphocyte activation molecule associated protein; SLAM associated protein; T cell signal transduction molecule SAP; SH21A_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領域 心血管  免疫學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SH2D1A/SAP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
產品介紹 background:
SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).xy-12044R    TWF2細胞骨架結合蛋白2抗體
xy-11536R    TUB 1TUB蛋白抗體
xy-2354R    TBX-5轉錄因子Tbx5抗體
xy-8332R    TM9SF4跨膜蛋白9家族成員4抗體
xy-7881R    TRIM29共濟失調毛細血管擴張癥D相關蛋白抗體
xy-8164R    TBL1Y轉導β樣蛋白1抗體
xy-7925R    TLK2絲氨酸/蘇氨酸激酶TLK2抗體
xy-8299R    TXNRD1硫氧環蛋白還原酶1抗體
xy-8335R    TMEM173跨膜蛋白173抗體
xy-8336R    TMEM147跨膜蛋白147抗體
xy-8523R    TET1Ten-eleven轉運基因1蛋白抗體
xy-9414R    TSPAN5四分子交聯體5抗體（四旋蛋白）
xy-9415R    TSPAN6四分子交聯體6抗體（四旋蛋白）
xy-9416R    TALLA-1T細胞急性淋巴母細胞白血病相關抗原1抗體
xy-9417R    TM4SF3TM4SF3蛋白抗體
xy-9419R    TSPAN10四分子交聯體10抗體（四旋蛋白）
xy-9448R    TSPAN9四分子交聯體9/四旋蛋白抗體
xy-9420R    TSPAN12四分子交聯體12抗體（四旋蛋白）
xy-9421R    TSPAN13四分子交聯體13抗體（四旋蛋白）
xy-9423R    TSPAN16四分子交聯體16抗體（四旋蛋白）
xy-9426R    TSPAN20四分子交聯體20抗體（四旋蛋白）
xy-4886R    TREM1髓系細胞觸發受體1抗體
xy-11177R    Trypsin Inhibitor胰蛋白酶抑制劑抗體
xy-8599R    T2R6味覺感受器蛋白T2R6抗體
xy-8650R    T2R38味覺感受器蛋白T2R38抗體
xy-8729R    TPH25色氨酸羥化酶2抗體
xy-11439R    TXNDC11硫氧還蛋白11抗體
xy-11313R    TUBA4A微管蛋白4α抗體
xy-11310R    DYNLT1動力蛋白輕鏈
xy-11035R    TNFAIP8L2腫瘤壞死因子誘導蛋白8樣蛋白2/TNFα-IP 8L2抗體
xy-11311R    TPOR血小板生成素受體抗體
xy-11183R    TMPRSS5跨膜絲氨酸蛋白酶5抗體
xy-11331R    TBR2脫中胚蛋白抗體
xy-8528R    TPP1細胞生長抑制基因1蛋白抗體
xy-0706R    T4/L-Thyroxine甲狀腺素T4抗體