SH2結(jié)構(gòu)域轉(zhuǎn)化蛋白1抗體

英文名稱(chēng) SHC
中文名稱(chēng) SH2結(jié)構(gòu)域轉(zhuǎn)化蛋白1抗體
別    名 p46; p52; p52 SHC; p52SHC; p66; p66 SHC; p66SHC; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC 1; SHC A; Shc; SHC transforming protein 1; SHC transforming protein; SHC1; SHCA; Src homology 2 domain containing transforming protein C1.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHC
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Function:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.xy-3359R    Phospho-MARCKS (Ser162)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-0668R    Met (c Met)肝細(xì)胞生長(zhǎng)因子受體抗體
xy-6779R    phospho-MAP3K9+MAP3K10(Thr312 + Thr266)磷酸化絲裂原活化蛋白激酶3K9抗體
xy-6780R    TYRO3受體酪氨酸激酶抗體
xy-6778R    MAP3K9絲裂原活化蛋白激酶3K9抗體
xy-7558R    MC3 Receptor黑素皮質(zhì)素3受體抗體
xy-1988R    MeninMenin抑癌蛋白抗體
xy-8542R    MSH3錯(cuò)配修復(fù)蛋白3抗體
xy-1983R    MCM7微小染色體維持缺陷蛋白7抗體
xy-1985R    MCP-2單核細(xì)胞趨化蛋白2抗體(小鼠)
xy-1986R    MCP-3單核細(xì)胞趨化蛋白3抗體
xy-1987R    MCP-3單核細(xì)胞趨化蛋白3抗體
xy-1989R    MIP4巨噬細(xì)胞炎癥蛋白18抗體
xy-1990R    MITFMITF相關(guān)轉(zhuǎn)錄因子抗體
xy-1992R    MTOR雷帕霉素靶蛋白抗體
xy-1993R    Muc2粘蛋白-2/上皮膜抗原2抗體
xy-1994R    Mucin 4粘蛋白4抗體
xy-0924R    Mafav-maf 肌腱膜纖維肉瘤癌基因同源物A抗體
xy-1344R    MMP-10基質(zhì)金屬蛋白酶-10抗體
xy-0913R    Mtp53(N235K N239Y)突變型P53抗體
xy-0909R    Microsporidia protien蜜蜂微孢子蟲(chóng)蛋白抗體
xy-1991R    MMP24基質(zhì)金屬蛋白酶-24抗體
xy-4727R    Mannose Receptor巨噬細(xì)胞甘露糖受體抗體
xy-1022R    Mucin 5AC胃粘液素抗體
xy-0985R    MMP-20基質(zhì)金屬蛋白酶20抗體
xy-0916R    Uromucoid尿調(diào)節(jié)蛋白抗體
xy-1400R    MEF2A肌細(xì)胞增強(qiáng)因子2抗體
xy-2442R    MyoD1/Myf3肌原調(diào)節(jié)蛋白抗體
xy-1155R    MASH1神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子抗體
xy-4120R    MHC class I antigen B 15組織相關(guān)抗原HLA-B15抗體