8-羥基脫氧鳥苷抗體

英文名稱 8-OHdG
中文名稱 8-羥基脫氧鳥苷抗體
別    名 8 Hydroxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8 hydroxy 2’ deoxyguanosine; 8 hydroxyguanine; 8 hydroxyguanosine; 8 OHG; 8-OHG; 8OG; 8OHdG; 8OHG; 8 Oxoguanine; 8 hydroxyguanine; 8 Oxo 7,8 dihydroguanine; 8 oxo Gua; 8 oxoG.
    
說 明 書 0.1ml  0.2ml  
產品類型 藥物與化合物抗體 
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 8-OHdG
產品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 0.283kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated to 8-OHdG
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.

Function:
Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.

Subcellular Location:xy-5698R    phospho-RAC1(Ser71)磷酸化細胞遷移誘導因子5抗體
xy-5692R    Phospho-RelB(Ser573)磷酸化核轉錄因子NFKB-RelB蛋白抗體
xy-5695R    phospho-RPH3AL(Ser232)磷酸化Ras相關GTP結合蛋白抗體
xy-4185R    RelB轉錄因子RelB蛋白抗體
xy-4182R    RPA32復制因子A蛋白2
xy-5693R    phospho-RPA2(Thr21)磷酸化復制因子A蛋白2抗體
xy-4183R    RPH3ALRas相關GTP結合蛋白抗體
xy-5690R    phospho-Rab24(Ser95)磷酸化ras基因相關蛋白Rab24抗體
xy-5691R    phospho-Rab24(Tyr17)磷酸化ras基因相關蛋白Rab24抗體
xy-5687R    phospho-RGS19(Ser24)磷酸化G蛋白信號轉導調節因子19抗體
xy-5688R    phospho-RGS19(Ser151)磷酸化G蛋白信號轉導調節因子19抗體
xy-5682R    phospho-RPS6KA1(Ser352)磷酸化絲氨酸/蘇氨酸激酶p90RSK蛋白抗體
xy-5684R    phospho-RAD51(Tyr315)磷酸化Rad51抗體
xy-5685R    phospho-RUNX2(Ser451)磷酸化成骨特異性轉錄因子抗體
xy-5689R    phospho-RGS19(Tyr143)磷酸化G蛋白信號轉導調節因子19抗體
xy-3867R    RGS19G蛋白信號轉導調節因子19抗體
xy-6142R    RING1環指蛋白1抗體
xy-4132R    MST1R原癌基因c-Met相關酪氨酸激酶抗體
xy-5489R    phospho-Ron(Ser1349)磷酸化原癌基因c-Met相關酪氨酸激酶抗體
xy-5795R    Robo4腫瘤血管內皮調節蛋白Robo4抗體
xy-5794R    Robo軸突導向受體抗體
xy-1560R    Reelin絡絲蛋白抗體
xy-13677R    RUSC1RUSC1抗體
xy-13678R    RUSC2RUSC2抗體
xy-13698R    RAGEF2RAGEF2蛋白抗體
xy-12389R    RAB23G蛋白偶聯受體RAB23抗體
xy-15502R    RGS14 G蛋白信號調節因子14抗體
xy-7343R    RANK核轉錄因子NF-κB受體/核因子kB受體活化因子抗體
xy-3024R    phospho-RUNX1 (Ser266)磷酸化急性髓細胞白血病1蛋白抗體
xy-9362R    phospho-Proteasome 20S beta 7(Ser214)磷酸化蛋白酶體PSMβ7抗體
xy-3808R    Radixin根蛋白抗體
xy-6887R    Rb2 p130視網膜母細胞瘤樣蛋白2抗體
xy-2802R    RXR gamma維甲酸受體G抗體
xy-13280R    RASA1Rho GTP酶激活蛋白1/血管畸形骨肥大綜合征相關蛋白抗體