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當(dāng)前位置:上海信裕生物科技有限公司>>抗體>>一抗>> 分泌素受體抗體
產(chǎn)品型號
品 牌Abcam
廠商性質(zhì)生產(chǎn)商
所 在 地上海
更新時(shí)間:2018-06-04 02:35:42瀏覽次數(shù):499次
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英文名稱 Secretin receptor
中文名稱 分泌素受體抗體
別 名 6530402O03Rik, MGC102218, MGC93381, SCTR, SR; Secretin receptor; SCT-R; SCTR_HUMAN.
說 明 書 0.2ml
研究領(lǐng)域 信號轉(zhuǎn)導(dǎo) 生長因子和激素 細(xì)胞膜受體 內(nèi)分泌病 細(xì)胞類型標(biāo)志物
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
細(xì)胞定位 細(xì)胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human Secretin receptor
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產(chǎn)品介紹 background:
The receptor for secretin is a class 2 (or class B) G protein coupled receptor that signals through Gs to stimulate cAMP production. Along with its traditional role in the pancreas, studies in secretin-deficient mice have shown miscommunication between the CA3 Schaffer collateral and CA1 pyramidal neurons, causing a deficiency in synaptic transmission. This miscommunication of CA1 dendrites is found in Autism, Rett Syndrome, and most forms of mental retardation, suggesting secretin could be a potential target for treatment of these disorders.
Function:
This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
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