神經管畸形相關蛋白VANGL2抗體

英文名稱 VANGL2
中文名稱 神經管畸形相關蛋白VANGL2抗體
別    名 Homolog of Drosophila strabismus; KIAA1215; Loop tail associated protein; loop tail protein 1 homolog; Loop-tail protein 1 homolog; LPP 1; LPP1; LTAP; STB 1; STB1; STBM 1; STBM; STBM1; Strabismus 1; van Gogh like protein 2; Van Gogh-like protein 2; Vang (van gogh, Drosophila) like 2; Vang like 2 (van gogh, Drosophila); vang like 2; vang like protein 2; Vang-like protein 2; VANG2_HUMAN; VANGL 2; Vangl2.
  
說 明 書 0.2ml  
研究領域 心血管  發育生物學  神經生物學  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VANGL2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
The Vang family of proteins are integral membrane proteins that are homologs of the Drosophila tissue polarity gene strabismus. The gene encoding for Van Gogh-like protein 1 (Vangl1), also designated Strabismus 2 (STB2), localizes to chromosome 1p11-p13.1. Van Gogh-like protein 2 (Vangl2), also designated Strabismus1 (STB1), localizes on chromosome 1q22-q23. Vangl1 is expressed in testis and ovary, but also in gastric and pancreatic cancer. Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both down-regulated in several cancer cell lines and primary tumors.
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.

Function:
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity). xy-0099R    TGF beta 3 propeptide轉移生長因子β3抗體（TGFβ3）
xy-0117R    TGF beta Receptor II轉移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）
xy-0638R    TGF beta Receptor I轉移生長因子β受體1抗體
xy-0447R    Thyroid peroxidase甲狀腺過氧化物酶抗體
xy-1202R    TRADD腫瘤壞死因子受體1相關死亡域蛋白抗體
xy-1217R    TSARG3生精細胞凋亡相關基因3抗體
xy-0339R    T3三碘甲狀腺素T3抗體
xy-0632R    Thioster-containing protein 1按蚊硫酯包含蛋白-1抗體
xy-1909R    omerase Binding Protein, P23端粒酶結合蛋白P23抗體
xy-1923R    TSARG6生精細胞凋亡相關基因6抗體
xy-0176R    Trk C酪氨酸激酶C抗體(神經生長因子受體的一種)
xy-1243R    Trop-2原肌球蛋白抗體
xy-0460R    TSHR促甲狀腺素受體抗體
xy-0206R    TSHR (CT)促甲狀腺素受體抗體（C端）
xy-3439R    Phospho-TAK1(Thr184 + Thr187)磷酸化轉化生長因子β活化激酶1
xy-3440R    Phospho-TBK1 (Ser172)磷酸化NF-κB活化激酶抗體
xy-3586R    Tuberin馬鈴薯球蛋白(結節性硬化)抗體
xy-3441R    Phospho-Tuberin (Ser1387)磷酸化馬鈴薯球蛋白(結節性硬化)抗體
xy-3442R    Phospho-Tuberin(Ser939)磷酸化馬鈴薯球蛋白(結節性硬化)抗體
xy-3443R    Phospho-Tuberin(Tyr1571)磷酸化馬鈴薯球蛋白(結節性硬化)抗體
xy-3444R    Phospho-TSC2 (Thr1462)磷酸化馬鈴薯球蛋白(結節性硬化)抗體
xy-3445R    Phospho-Tuberin (Thr927)磷酸化馬鈴薯球蛋白(結節性硬化)抗體
xy-3446R    phospho-Tau protein(Ser396)磷酸化微管相關蛋白抗體
xy-3587R    TNK1非受體型酪氨酸蛋白激酶Tnk1抗體
xy-3450R    Phospho-TNK1 (Tyr277)磷酸化非受體型酪氨酸蛋白激酶Tnk1抗體
xy-3451R    phospho-TOPO II Alpha (Ser1106)磷酸化DNA拓普西異構酶Ⅱ抗體
xy-3588R    TORC1環腺苷酸應答元件結合蛋白轉錄共激活因子TORC1抗體
xy-3453R    Phospho-Torc1 (Ser151)磷酸化CREB轉錄共激活因子TORC1抗體
xy-3590R    TORC2CREB轉錄共激活因子TORC2抗體
xy-0093R    TNF beta腫瘤壞死因子β抗體（TNFβ）
xy-1280R    TCF7L2轉錄因子7類似物2抗體
xy-0507R    TBX2血栓素B2(一種新發現的抑癌基因)抗體