血管內皮細胞粘附分子抗體

英文名稱 VCAM-1
中文名稱 血管內皮細胞粘附分子抗體
別    名 VCAM1; CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; L1CAM; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; INCAM-100; V-CAM 1; VCAM1_HUMAN.
   
說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  細胞生物  細胞粘附分子  血管內皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rabbit, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VCAM-1/CD106/L1CAM
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells. 
xy-1143R    STAT6信號轉導和轉錄激活因子6抗體
xy-0685R    SYK非受體型酪氨酸蛋白激酶抗體
xy-0679R    SYVN1滑膜細胞凋亡抑制物1抗體
xy-0277R    SELS炎癥負調控因子蛋白抗體
xy-1278R    8-OHdG8-羥基脫氧鳥苷抗體
xy-0132R    SARS putative orflab polyprotein冠狀病毒抗體
xy-9514R    PI14蛋白酶抑制劑14抗體
xy-4536R    Streptococcus suis 22型豬鏈球菌菌體蛋白抗體
xy-1619R    Smad1細胞信號轉導分子Smad-1抗體
xy-3403R    Phospho-SHP2 (Tyr542)磷酸化蛋白酪氨酸磷酸酶2抗體
xy-3405R    Phospho-SHP2 (Tyr584)磷酸化蛋白酪氨酸磷酸酶2抗體
xy-3568R    SMC1染色體結構維持蛋白1抗體
xy-3406R    Phospho-SMC1 (Ser360)磷酸化染色體結構維持蛋白質１抗體
xy-3570R    StAR促黃體激素誘導蛋白抗體
xy-5724R    STK36絲氨酸/蘇氨酸激酶36融合同源蛋白抗體
xy-6577R    S100P binding proteinS100P結合蛋白抗體
xy-6578R    SAMD14SAMD14抗體
xy-7506R    SMOC2分泌模塊化鈣結合蛋白2抗體（平滑肌相關蛋白2）
xy-6787R    SLC26A4鈉碘單獨轉運蛋白SLC26A4抗體
xy-7507R    Sprouty 2快速發育生長因子同源蛋白2抗體
xy-7078R    SPNS1SPNS1抗體
xy-7519R    SEMA4A跨膜蛋白SEMA4A抗體
xy-11362R    SNAP23突觸相關蛋白23抗體
xy-11361R    SAP97突觸相關蛋白97抗體
xy-11374R    Synaptogyrin 2神經細胞囊泡循環蛋白2抗體
xy-11363R    SNAP29突觸相關蛋白29抗體
xy-11364R    SNAPIN突觸相關蛋白25結合蛋白抗體
xy-11365R    SV2B突觸泡蛋白2B抗體
xy-11366R    SV2C突觸泡蛋白2C抗體
xy-11367R    SYNPR/Synaptoporin突觸囊泡蛋白抗體
xy-11368R    Sec8胞吐分泌蛋白Sec8抗體
xy-6906R    SEPT6細胞分化蛋白SEPT6抗體
xy-11379R    Syntenin 1多配體聚糖結合蛋白1抗體
Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Subunit:
Binds to ECMV-D capsid proteins and acts as a receptor for this virus.